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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Post-mortem 1.5T MR quantification of regular anatomical brain structures.

Wolf-Dieter Zech^1,2, Anna-Lena Hottinger³, Nicole Schwendener³

¹Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012, Bern, Switzerland. Wolf-Dieter.Zech@irm.unibe.ch.

International Journal of Legal Medicine

|February 14, 2016

Summary

This summary is machine-generated.

Post-mortem magnetic resonance (MR) quantification allows simultaneous measurement of T1, T2 relaxation times, and proton density (PD) in brain tissues. These quantitative values can differentiate anatomical structures and show slight temperature dependence, aiding future forensic imaging analysis.

Keywords:

Brain Forensic MR quantification Neuroimaging Post-mortem magnetic resonance imaging (PMMR)

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Area of Science:

Forensic Radiology
Medical Imaging Physics
Neuroimaging

Background:

Post-mortem magnetic resonance (MR) quantification is an emerging technique for analyzing deceased individuals.
This method allows for simultaneous quantification of T1 and T2 relaxation times and proton density (PD) in tissues and organs.

Purpose of the Study:

To assess quantitative T1, T2, and PD values in regular anatomical brain structures using a 1.5T MR scanner.
To correlate these quantitative values with corpse temperatures during post-mortem MR imaging.

Main Methods:

A prospective study involving 30 forensic cases scanned with an MR quantification sequence prior to autopsy.
Quantitative T1, T2, and PD values were assessed in specific cerebrum and brainstem/cerebellum structures.
Body temperature was recorded during MR scans for correlation analysis.

Main Results:

Significant differences in quantitative T1, T2, and PD values were found among various anatomical brain structures.
These quantitative values successfully characterized and differentiated brain structures.
A slight temperature dependence was observed, primarily for T1 values, which increased with rising temperature.

Conclusions:

Quantitative MR parameters (T1, T2, PD) can differentiate anatomical brain structures in post-mortem imaging.
The findings establish a baseline for quantitative analysis of brain tissues and support future computer-aided diagnosis of pathologies.