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Updated: Mar 25, 2026

A Mouse Model of Lumbar Spine Instability
Published on: April 23, 2021
Degenerative disease of the lumbar spine
1Departamento Científico, Fundación Kovacs, Palma de Mallorca, España; Red Española de Investigadores en Dolencias de la Espalda (REIDE), España.
Abstract:
In the last 25 years, scientific research has brought about drastic changes in the concept of low back pain and its management. Most imaging findings, including degenerative changes, reflect anatomic peculiarities or the normal aging process and turn out to be clinically irrelevant; imaging tests have proven useful only when systemic disease is suspected or when surgery is indicated for persistent spinal cord or nerve root compression. The radiologic report should indicate the key points of nerve compression, bypassing inconsequential findings. Many treatments have proven inefficacious, and some have proven counterproductive, but they continue to be prescribed because patients want them and there are financial incentives for doing them. Following the guidelines that have proven effective for clinical management improves clinical outcomes, reduces iatrogenic complications, and decreases unjustified and wasteful healthcare expenditures.
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