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Updated: Mar 25, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Trinculo: Bayesian and frequentist multinomial logistic regression for genome-wide association studies of
1Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, UK Christ Church, University of Oxford, St Aldates, Oxford OX1 1DP, UK.
Motivation:
For many classes of disease the same genetic risk variants underly many related phenotypes or disease subtypes. Multinomial logistic regression provides an attractive framework to analyze multi-category phenotypes, and explore the genetic relationships between these phenotype categories. We introduce Trinculo, a program that implements a wide range of multinomial analyses in a single fast package that is designed to be easy to use by users of standard genome-wide association study software.
Availability And Implementation:
An open source C implementation, with code and binaries for Linux and Mac OSX, is available for download at http://sourceforge.net/projects/trinculo
Supplementary Information:
Supplementary data are available at Bioinformatics online.
Contact:
lj4@well.ox.ac.uk.
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