[Reevaluation of transperineal prostate biopsy]

In these recent over twenty years, transrectal prostate biopsy takes predominant place in diagnosing prostate cancer for its relatively convenient procedure and low cost. In contrast, transperineal biopsy approach is much less popular. However, transrectal prostate biopsy has disadvantages of"blind region"in the anterior apex regions of the prostate gland and relatively high risk of biopsy associated sepsis. The transperineal biopsy approach is again gaining attention and even becoming a mainstream approach. The advantages of transperineal prostate biopsy are the following: a high positive rate, particularly in the detection of tumors at the anterior or apical prostate; accurate assessment of the volume and Gleason score of prostate cancer; the possibility of providing information about the spatial distribution of the cancer; good consistency of pathology with radical resection; and a lower infection rate, making it suitable for patients with a high infection risks. The expansion of transperineal biopsy has been propagated by the increase in multiparametric MRI-guided biopsies, which often use the transperineal approach.