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Updated: Mar 25, 2026

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Hydrogels made from chitosan and silver nitrate
Marek Kozicki1, Marek Kołodziejczyk2, Małgorzata Szynkowska3
1Department of Man-Made Fibres, Faculty of Material Technologies and Textile Design, Lodz University of Technology, Żeromskiego 116, 90-924 Łódź, Poland; GeVero Co., Tansmana 2/11, 92-548 Łódź, Poland.
Abstract:
This work describes a gelation of chitosan solution with silver nitrate. Above the critical concentration of chitosan (c*), continuous hydrogels of chitosan-silver can be formed. At lower concentrations, the formation of nano- and micro-hydrogels is discussed. The sol-gel analysis was performed to characterise the hydrogels' swelling properties. Moreover, the following were employed: (i) mechanical testing of hydrogels, (ii) inductively coupled plasma-optical emission spectroscopy (ICP-OES) for the measurement of silver concentration, (iii) scanning electron microscopy (SEM) to examine the morphology of products obtained, and (iv) dynamic light scattering (DLS) and UV-vis spectrophotometry to examine products formed at low concentration of chitosan (c

