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Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6

Arnold van Loevezijn1, Jennifer Venhorst1, Wouter I Iwema Bakker1

  • 1Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.

Bioorganic & Medicinal Chemistry Letters
|February 16, 2016
PubMed

Keywords:
5-HT(6) receptorMolecular modelingNon-basic 5-HT(6) antagonistsN′-(Arylsulfonyl)pyrazoline-1-carboxamidines

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