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Studying auditory verbal hallucinations using the RDoC framework.

Judith M Ford1,2

  • 1San Francisco VA Medical Center, San Francisco, California, USA.

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|February 16, 2016
PubMed
Summary
This summary is machine-generated.

Researchers explored the neurobiology of auditory verbal hallucinations (AVH) using the Research Domain Criteria (RDoC) framework. Findings suggest that altered neural activity and connectivity related to intentions may better explain AVH than reduced cortical suppression.

Keywords:
AgencyAuditory verbal hallucinationsEEGERPN1RDoC

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Auditory verbal hallucinations (AVH) are a core symptom of psychosis.
  • The Research Domain Criteria (RDoC) offers a framework for studying mental disorders based on functional domains.
  • The RDoC construct of 'agency' aligns with the subjective experience of AVH, where voices may sound 'nonself'.

Purpose of the Study:

  • To investigate the neurobiological underpinnings of AVH using an RDoC approach.
  • To examine the role of the sense of agency in the phenomenology of AVH.
  • To identify neural mechanisms sensitive to AVH.

Main Methods:

  • Utilized a vocalization paradigm, adapted from nonhuman primate research, to study the sense of agency.
  • Measured auditory event-related potentials (ERPs), specifically the N1 component.
  • Analyzed electroencephalography (EEG) synchrony preceding speech onset.
  • Examined motor activity preceding talking and frontotemporal connectivity during talking.

Main Results:

  • Auditory N1 ERP was suppressed during vocalization, with EEG synchrony preceding speech related to this suppression.
  • Both N1 suppression and preceding EEG synchrony were reduced in patients with schizophrenia.
  • Reduced cortical suppression was observed in various psychotic disorders and at-risk youth but was not directly linked to AVH.
  • Motor activity preceding talking and frontotemporal connectivity during talking were sensitive to AVH.

Conclusions:

  • The RDoC construct of agency provides a relevant framework for studying AVH.
  • Reduced cortical suppression is a general finding in psychosis but not specific to AVH.
  • Neural activity and connectivity associated with intentions to act may be more pertinent for understanding agency and predictions in AVH.