Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

The bone & joint journal·2026
Same author

Residence in a rural setting is associated with lower five-year survival rates in patients that undergo spine surgery for breast cancer metastatic to the spine: A propensity matched analysis.

North American Spine Society journal·2026
Same author

High-Riding Vertebral Artery in Cervical Spine Surgery: A Review of Preoperative Identification and Surgical Implications.

Cureus·2026
Same author

From anticipation to achievement: evaluating the impact of preoperative expectations on postoperative patient satisfaction in lumbar decompression surgeries.

Journal of neurosurgery. Spine·2026
Same author

Development of a Radiographic Scoring System to Estimate Acetabular Protrusion Risk in Patients with Osteolytic Periacetabular Metastases.

The Journal of bone and joint surgery. American volume·2026
Same author

The association between intraoperative ketamine administration and reduced postoperative opioid consumption among chronic opioid users after multilevel lumbar fusion.

Journal of neurosurgery. Spine·2026

Related Experiment Video

Updated: Mar 25, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
09:14

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Published on: April 5, 2016

9.4K

Tissue engineering advances in spine surgery.

Melvin C Makhni1, Jon-Michael E Caldwell1, Comron Saifi2

  • 1Department of Orthopedic Surgery, New York-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA.

Regenerative Medicine
|February 16, 2016
PubMed
Summary

Tissue-engineered bone grafts using nanoscale technology offer a promising alternative to traditional grafts in spine surgery. These advanced materials aim to overcome the limitations of autografts and allografts for better patient outcomes.

Keywords:
biomimeticbone graftbone morphogenetic proteindisc regenerationscaffoldsspinestem cellssurgerytissue engineering

More Related Videos

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

561
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.8K

Related Experiment Videos

Last Updated: Mar 25, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
09:14

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Published on: April 5, 2016

9.4K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

561
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.8K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Spine Surgery

Background:

  • Autografts and allografts present significant challenges in bone grafting, including limited supply, donor site morbidity, and immunological risks.
  • The demand for effective bone graft substitutes is high, particularly in complex spinal fusion procedures.
  • Current limitations necessitate the development of innovative tissue-engineered solutions.

Purpose of the Study:

  • To review recent advancements in nanoscale tissue-engineered bone graft substitutes for spine surgery.
  • To evaluate biomimetic scaffolds, bone morphogenetic proteins, and mesenchymal stem cells in bone regeneration.
  • To explore strategies for intervertebral disc regeneration.

Main Methods:

  • Literature review focusing on nanoscale technologies in bone tissue engineering.
  • Evaluation of biomimetic 3D scaffolds and their role in spinal applications.
  • Analysis of bone morphogenetic proteins and mesenchymal stem cell therapies for bone repair.

Main Results:

  • Nanoscale technologies are enhancing the osteoconductive and osteoinductive properties of bone graft substitutes.
  • Biomimetic scaffolds provide a conducive environment for cell proliferation and differentiation.
  • Mesenchymal stem cells and bone morphogenetic proteins show potential in promoting bone formation.

Conclusions:

  • Nanoscale tissue engineering holds significant promise for developing superior bone graft substitutes in spine surgery.
  • Further research into biomimetic scaffolds and cell-based therapies can improve spinal fusion and regeneration.
  • These advancements aim to overcome the limitations of current grafting methods, improving patient recovery and surgical success.