Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Relative Risk01:12

Relative Risk

2.5K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.5K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

783
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
783

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative.

Seminars in arthritis and rheumatism·2021
Same author

Prologue: 2020 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).

The Journal of rheumatology·2021
Same author

European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance.

Annals of the rheumatic diseases·2021
Same author

Incidence of and Risk Factors for Heart Failure in Patients With Psoriatic Disease: A Cohort Study.

Arthritis care & research·2021
Same author

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

Rheumatology (Oxford, England)·2021
Same author

Systematic literature review of non-topical treatments for early, untreated (systemic therapy naïve) psoriatic disease: a GRAPPA initiative.

Rheumatology advances in practice·2021

Related Experiment Video

Updated: Mar 25, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

19.1K

Modified Framingham Risk Factor Score for Systemic Lupus Erythematosus.

Murray B Urowitz1, Dominique Ibañez2, Jiandong Su2

  • 1From the University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.M.B. Urowitz, MD, FRCPC, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; D. Ibañez, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; J. Su, MB, BSc University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; D.D. Gladman, MD, FRCPC, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. m.urowitz@utoronto.ca.

The Journal of Rheumatology
|February 17, 2016
PubMed
Summary

A modified Framingham Risk Factor Score (FRS), with each item multiplied by 2, better predicts coronary artery disease (CAD) risk in patients with systemic lupus erythematosus (SLE). This adjusted score, the 2FRS, improves cardiovascular risk assessment for this vulnerable population.

Keywords:
CARDIOVASCULAR DISEASEFRAMINGHAM RISK SCORESYSTEMIC LUPUS ERYTHEMATOSUS

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K
Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

6.4K

Related Experiment Videos

Last Updated: Mar 25, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

19.1K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K
Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

6.4K

Area of Science:

  • Cardiology
  • Rheumatology
  • Epidemiology

Background:

  • Systemic lupus erythematosus (SLE) is associated with a higher prevalence of coronary artery disease (CAD).
  • The traditional Framingham Risk Factor Score (FRS) often underestimates cardiovascular risk in SLE patients.
  • Accurate risk stratification is crucial for timely intervention and management of CAD in SLE.

Purpose of the Study:

  • To evaluate the accuracy of an adjusted Framingham Risk Factor Score (mFRS) in predicting CAD in patients with SLE.
  • To determine the optimal multiplier for an mFRS that best reflects the increased CAD risk in SLE.
  • To compare the predictive performance of the modified FRS (mFRS) against the traditional FRS.

Main Methods:

  • A cohort of SLE patients without prior CAD or diabetes was analyzed.
  • A modified FRS (mFRS) was calculated using multipliers of 1.5, 2, 3, or 4.
  • Sensitivity, specificity, and predictive ability of FRS and mFRS were assessed in a time-dependent analysis.

Main Results:

  • A multiplier of 2 (resulting in the 2FRS) demonstrated the best sensitivity and specificity.
  • The 2FRS classified significantly more SLE patients as moderate/high risk (17.3%) compared to the classic FRS (2.4%).
  • Time-dependent analysis showed the 2FRS had a higher hazard ratio (4.37) for predicting CAD events than the classic FRS (3.22).

Conclusions:

  • The modified FRS with a multiplier of 2 (2FRS) provides a more accurate prediction of CAD in patients with SLE.
  • This adjusted risk score improves cardiovascular risk assessment for individuals with systemic lupus erythematosus.
  • Implementing the 2FRS can aid in better identifying SLE patients who require closer monitoring and preventative strategies for CAD.