Related Experiment Video
Updated: Mar 25, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
NETIMIS: Dynamic Simulation of Health Economics Outcomes Using Big Data
Owen A Johnson1,2, Peter S Hall3, Claire Hulme3
1School of Computing, Leeds MRC Bioinformatics Research Centre, The University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. o.a.johnson@leeds.ac.uk.
None:
Many healthcare organizations are now making good use of electronic health record (EHR) systems to record clinical information about their patients and the details of their healthcare. Electronic data in EHRs is generated by people engaged in complex processes within complex environments, and their human input, albeit shaped by computer systems, is compromised by many human factors. These data are potentially valuable to health economists and outcomes researchers but are sufficiently large and complex enough to be considered part of the new frontier of 'big data'. This paper describes emerging methods that draw together data mining, process modelling, activity-based costing and dynamic simulation models. Our research infrastructure includes safe links to Leeds hospital's EHRs with 3 million secondary and tertiary care patients. We created a multidisciplinary team of health economists, clinical specialists, and data and computer scientists, and developed a dynamic simulation tool called NETIMIS (Network Tools for Intervention Modelling with Intelligent Simulation; http://www.netimis.com ) suitable for visualization of both human-designed and data-mined processes which can then be used for 'what-if' analysis by stakeholders interested in costing, designing and evaluating healthcare interventions. We present two examples of model development to illustrate how dynamic simulation can be informed by big data from an EHR. We found the tool provided a focal point for multidisciplinary team work to help them iteratively and collaboratively 'deep dive' into big data.
More Related Videos
Related Concept Videos
Statistical Methods for Analyzing Epidemiological Data
Modeling with Differential Equations
Causality in Epidemiology
Steps in Outbreak Investigation
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model
Population Growth

