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Multifunctional Antioxidants: Regenerable Radical-Trapping and Hydroperoxide-Decomposing Ebselenols
Shailesh Kumar1, Jiajie Yan2, Jia-Fei Poon2
1Department of Chemistry, Indian Institute of Science Education and Research (IISER), Bhopal-, 462066, India.
Abstract:
Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than α-tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25 μm, the ebselenol derivatives showed minimal toxicity in pre-osteoblast MC3T3 cells.
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