Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioplastics01:27

Bioplastics

18
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
18
Microbial Bioremediation of Plastics01:28

Microbial Bioremediation of Plastics

30
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
30

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injectable gelatin-PEG hydrogels obtained <i>via</i> cytochrome C-mediated polymerization.

Organic & biomolecular chemistry·2026
Same author

Questing for Integrin Targeting Theranostics for Cancer Cell-Selective Molecules.

ACS omega·2026
Same author

Cross-Linking PEG Microgels with Mesoporous Organosilica Nanoparticles to Engineer Microporous Annealed Particle Scaffold Properties.

ACS omega·2026
Same author

Insights from aquaporin structures into drug-resistant sleeping sickness.

eLife·2026
Same author

Two solutions for efficient light-harvesting in phototrophic <i>Gemmatimonadota</i>.

mSystems·2025
Same author

Dual spatio-functional control of a fission yeast-based bioprocessor upon chemical induction.

RSC chemical biology·2025

Related Experiment Video

Updated: Mar 25, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

17.9K

Biodegradable Peptide-Silica Nanodonuts.

Laura Maggini1, Leana Travaglini1, Ingrid Cabrera1

  • 1Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, 67000, Strasbourg, France.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 17, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed novel hybrid organosilica toroidal particles with peptide components. These biodegradable nanocarriers are effectively broken down by cancer cell enzymes, demonstrating potential for targeted drug delivery.

Keywords:
biodegradabilitybreakable particlesdrug deliveryhybrid organosilica particlesmaterials science

More Related Videos

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

8.3K
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

11.6K

Related Experiment Videos

Last Updated: Mar 25, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

17.9K
Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

8.3K
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

11.6K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Biology

Background:

  • Hybrid organosilica nanoparticles offer tunable properties for biomedical applications.
  • Peptide-functionalized nanocarriers can enhance cellular interactions and targeted delivery.
  • Biodegradable drug delivery systems are crucial for minimizing off-target effects.

Purpose of the Study:

  • To synthesize and characterize novel hybrid organosilica toroidal particles incorporating a peptide sequence.
  • To investigate the enzymatic degradation of these nanocarriers within cancer cells.
  • To evaluate the potential of these particles as biodegradable drug delivery vehicles.

Main Methods:

  • Synthesis of peptide-functionalized organosilica toroidal nanoparticles.
  • Cellular uptake and intracellular trafficking studies in HeLa cancer cells.
  • Investigation of nanoparticle degradation triggered by peptidase enzymes.
  • Doxorubicin loading and in vitro drug release studies.

Main Results:

  • Successful synthesis of hybrid organosilica toroidal particles with integrated peptide sequences.
  • Demonstrated high cellular uptake and exocytosis of the nanoparticles.
  • Confirmed enzymatic degradation of the nanocarriers upon internalization by cancer cells.
  • Showcased effective doxorubicin delivery into HeLa cells.

Conclusions:

  • Hybrid organosilica toroidal particles with peptide components are effectively degraded by cancer cell enzymes.
  • These biodegradable nanocarriers exhibit high cellular uptake and exocytosis.
  • The developed nanovectors show significant promise as biodegradable drug carriers for cancer therapy.