Related Experiment Video

Updated: Mar 25, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

10.1K

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers

Shiwei He1,2, Yancheng Zhong1,2, Cijun Shuai3

  • 1Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|February 17, 2016
PubMed

Insights

Nasopharyngeal carcinoma-associated gene 6 (NGX6) is frequently down-regulated in various cancers. This review highlights NGX6

Area of Science:

  • Molecular Biology
  • Oncology

Background:

  • Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein implicated in several cancers.
  • NGX6 expression is notably reduced in nasopharyngeal carcinoma (NPC), gastric, lung, liver, and colorectal cancers, particularly in metastatic cases.

Purpose of the Study:

  • To review the biological functions of NGX6.
  • To summarize regulatory factors influencing NGX6 expression.
  • To elucidate the potential of NGX6 as a therapeutic target for malignant diseases.

Main Methods:

  • Literature review of studies on NGX6.
  • Analysis of gene expression data in various cancers.
  • Examination of molecular mechanisms regulating NGX6.

Main Results:

  • NGX6 exhibits diverse functions including regulating gene expression, cell signaling, cell cycle, and angiogenesis.
  • NGX6 expression is negatively regulated by promoter methylation, histone H3K9, and Sp1.
  • Egr-1 positively regulates NGX6 expression.

Conclusions:

  • NGX6 plays a significant role in tumor suppression.
  • Understanding NGX6 regulation is crucial for developing novel cancer therapies.
  • NGX6 holds potential as a biomarker and therapeutic target for various cancers.
Keywords:
GrowthMetastasisNGX6Tumor suppressor

More Related Videos

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

316
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.5K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.9K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.9K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.4K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K