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Updated: Mar 25, 2026
Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
Published on: June 23, 2016
A simple aptamer-functionalized gold nanorods based biosensor for the sensitive detection of MCF-7 breast cancer
Yuan Li1, Yulong Zhang, Man Zhao
1Beijing Institute of Transfusion Medicine, Beijing Key Laboratory of Blood Safety and Supply Technologies, Beijing 100850, China. lszhan91@yahoo.com lovechina1980@163.com.
Abstract:
Herein, we describe a novel approach for the rapid diagnosis of human breast carcinoma MCF-7 cells with a detection limit of 100 cells mL(-1). In our strategy, the MCF-7 cells are specially recognized by mucin 1 protein (MUC-1) aptamer-functionalized gold nanorods (GNRs) through specific interactions, whose signals are simply read out by its unique localized surface plasmon resonance (LSPR) spectra.
