Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

18
Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These...
18
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

24
Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
24
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

25
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
25
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.1K
Antibiotic Selection00:57

Antibiotic Selection

62.0K
Overview
62.0K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

4.3K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of statins on aldosterone production in healthy adults: a randomized controlled study.

Journal of the Endocrine Society·2026
Same author

Adrenalectomy for mild autonomous cortisol secretion?

The lancet. Diabetes & endocrinology·2025
Same author

Salt Sensitivity of Blood Pressure in Black Individuals With Striatin and Lysine-specific Demethylase-1 Risk Alleles.

The Journal of clinical endocrinology and metabolism·2025
Same author

The renin-angiotensin-aldosterone system and salt sensitivity of blood pressure offer new insights in obesity phenotypes.

Obesity (Silver Spring, Md.)·2025
Same author

Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial.

The Journal of clinical endocrinology and metabolism·2025
Same author

A Simple Screening Tool Reduces Unnecessary Preoperative Evaluation for Cataract Surgery.

Quality management in health care·2024

Related Experiment Video

Updated: Mar 25, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
11:00

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Published on: August 31, 2015

8.8K

Singing the "Minocycline Blues".

Daniel G Federman, Andrea V Haas, John J Chang

    Connecticut Medicine
    |February 18, 2016
    PubMed
    Summary

    Minocycline medication can cause skin discoloration, known as minocycline dyschromia. This case highlights how it can be misdiagnosed as chronic actinic purpura, emphasizing the need for accurate diagnosis of drug-induced skin changes.

    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Cutaneous dyschromia, or skin discoloration, can arise from numerous medical conditions and pharmaceutical agents.
    • Accurate diagnosis is crucial for effective treatment and management of skin conditions.

    Observation:

    • A patient presented with skin discoloration initially suspected to be chronic actinic purpura.
    • Further investigation revealed the discoloration was a side effect of minocycline therapy.

    Findings:

    • The case demonstrates minocycline-induced dyschromia, a form of iatrogenic skin pigmentation.
    • The visual presentation of minocycline dyschromia can mimic other dermatoses like actinic purpura.

    Implications:

    • This case underscores the importance of a thorough medication history in diagnosing skin discoloration.

    More Related Videos

    Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
    08:25

    Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

    Published on: April 6, 2022

    2.4K
    High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
    09:09

    High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity

    Published on: November 16, 2016

    8.4K

    Related Experiment Videos

    Last Updated: Mar 25, 2026

    Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
    11:00

    Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

    Published on: August 31, 2015

    8.8K
    Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
    08:25

    Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

    Published on: April 6, 2022

    2.4K
    High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
    09:09

    High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity

    Published on: November 16, 2016

    8.4K
  • Awareness of drug-induced dyschromias can prevent misdiagnosis and guide appropriate patient management.
  • Clinicians should consider medication side effects when evaluating patients with unexplained skin pigmentary changes.