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Updated: Mar 25, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Copper-Catalyzed Annulation: A Method for the Systematic Synthesis of Phenanthridinium Bromide
Yuan-Ye Jhang1, Tai-Ting Fan-Chiang1, Jun-Min Huang1
1Department of Chemistry, Tamkang University , New Taipei City 25137, Taiwan.
Abstract:
A novel procedure for the Cu-catalyzed systematic synthesis of phenanthridinium bromide is reported. This transformation was achieved with direct construction of central pyridinium core by using an in situ formed biaryl imine as a substrate. Tolerance of a very wide variety of N-substituents is indicated; this has never previously been disclosed by other reports. Application of this method to synthesis of the natural alkaloid bicolorine, and its derivatives, was also carried out in only three synthetic steps from commercially available compounds.
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