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The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
Published on: April 19, 2019
The amygdalo-nigrostriatal network is critical for an optimal temporal performance
Mouna Es-seddiqi1, Nicole El Massioui1, Nathalie Samson1
1Université Paris-Saclay, Univ Paris-Sud, CNRS, UMR9197, Institut des Neurosciences Paris-Saclay, F 91405, Orsay, France CNRS, Orsay, F-91405 UMR 9197, Orsay, France.
Abstract:
The amygdalo-nigrostriatal (ANS) network plays an essential role in enhanced attention to significant events. Interval timing requires attention to temporal cues. We assessed rats having a disconnected ANS network, due to contralateral lesions of the medial central nucleus of the amygdala (CEm) and dopaminergic afferents to the lateral striatum, as compared to controls (sham and ipsilateral lesions of CEm and dopaminergic afferents to LS) in a temporal bisection task. ANS disconnection induced poorer temporal precision and increased response latencies to a short duration. The present results reveal a role of the ANS network in temporal processing.
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