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HDL function and subclinical atherosclerosis in juvenile idiopathic arthritis

Preethi Mani1, Kiyoko Uno1, MyNgan Duong1

  • 11 Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA ; 2 Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA ; 3 South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia ; 4 Department of Rheumatology, Cleveland Clinic, Cleveland, Ohio, USA.

Cardiovascular Diagnosis and Therapy
|February 18, 2016
PubMed

Insights

Juvenile idiopathic arthritis (JIA) alters high-density lipoprotein (HDL) function and cholesterol efflux, impacting vascular health. Further research is needed to understand the long-term cardiovascular risk implications in JIA patients.

Area of Science:

  • Cardiovascular Science
  • Rheumatology
  • Lipid Metabolism

Background:

  • Inflammation negatively affects high-density lipoprotein (HDL) properties and atherosclerosis progression.
  • The impact of early chronic inflammatory conditions on HDL function and vascular risk is under-researched.

Purpose of the Study:

  • To investigate HDL particle distribution and functionality in juvenile idiopathic arthritis (JIA).
  • To assess vascular risk markers, specifically carotid intima-medial thickness (cIMT), in JIA patients compared to controls.

Main Methods:

  • Compared HDL measures and cIMT between JIA patients and age-matched controls.
  • Assessed HDL cholesterol, total HDL, and large HDL particle levels.
  • Evaluated cholesterol efflux via ABCA1, ABCG1, and SR-B1 pathways.
  • Measured arylesterase activity and endothelial cell migration.

Main Results:

  • JIA patients had lower HDL cholesterol, total HDL, and large HDL particles.
  • JIA patients showed altered cholesterol efflux pathways (increased ABCA1, decreased ABCG1 and SR-B1).
  • Reduced arylesterase activity and endothelial cell migration were observed in JIA patients; no cIMT differences were found.

Conclusions:

  • Juvenile idiopathic arthritis is associated with significant alterations in HDL particle distribution and function.
  • Changes in HDL cholesterol efflux and non-lipid transport activities were noted in JIA.
  • The long-term cardiovascular risk implications of these HDL alterations in JIA require further investigation.
Abstract

Keywords:
Arthritisatherosclerosishigh-density lipoproteins (HDL) cholesteroljuvenile

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