Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders
Tatsuya Yamamoto1, Fuyuki Tateno2, Ryuji Sakakibara1,2
1Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
Plos One
|February 18, 2016
Summary
Patients with progressive supranuclear palsy (PSP) experience urinary storage and voiding dysfunctions. While storage issues are similar to Parkinson
Area of Science:
- Neurology
- Urology
Background:
- Autonomic urinary dysfunction is common in progressive supranuclear palsy (PSP).
- The prevalence and severity of urinary dysfunction in PSP compared to Parkinson's disease (PD) and multiple system atrophy (MSA) are not well understood.
Purpose of the Study:
- To compare urinary dysfunction characteristics in patients with PSP, PD, and MSA.
Main Methods:
- Assessed 47 PSP patients using urinary symptoms questionnaire and urodynamic studies.
- Compared results with 218 PD and 193 MSA patients.
Main Results:
- PSP patients showed urinary storage (57%) and voiding (56%) symptoms.
- Detrusor overactivity was found in 81% of PSP patients, similar to PD (69%) and MSA (67%).
- PSP patients had significantly higher postvoid residual volumes than PD patients (P < 0.01).
Conclusions:
- PSP patients experience diverse urinary dysfunctions.
- Urinary storage dysfunction in PSP is comparable to PD and MSA.
- Urinary voiding dysfunction is milder in PSP than MSA but more severe than PD.
- These urinary findings aid in differentiating PSP from PD and MSA.
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