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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Flow Cytometry01:23

Flow Cytometry

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: Mar 25, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

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Platelet Function Determined by Flow Cytometry: New Perspectives?

Sofia Ramström1, Anna L Södergren1, Nahreen Tynngård2

  • 1Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Seminars in Thrombosis and Hemostasis
|February 18, 2016
PubMed
Summary

Flow cytometry offers a practical method for assessing platelet function using minimal whole blood, even with low platelet counts. This technique is valuable for clinical settings and future research in platelet studies.

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Area of Science:

  • Hematology
  • Immunology
  • Clinical Diagnostics

Background:

  • Platelet function testing is crucial for diagnosing and managing various bleeding disorders.
  • Traditional methods can be time-consuming and require larger blood volumes.
  • Flow cytometry presents a sensitive and efficient alternative for platelet analysis.

Purpose of the Study:

  • To review the practical aspects of utilizing flow cytometry for platelet function testing.
  • To provide an overview of available reagents and experimental considerations.
  • To discuss the current and future clinical applications of flow cytometry in platelet studies.

Main Methods:

  • Utilizing flow cytometry to analyze platelet activation markers in response to various agonists.
  • Employing small volumes of whole blood for testing, accommodating low platelet counts.
  • Summarizing established protocols and critical factors for reliable results.

Main Results:

  • Flow cytometry allows for detailed assessment of multiple platelet functions simultaneously.
  • The method is adaptable to different clinical scenarios and requires minimal sample volume.
  • Key considerations for experimental setup and data interpretation are highlighted.

Conclusions:

  • Flow cytometry is a versatile and accessible tool for high-quality platelet function testing in clinical laboratories.
  • Its ability to use small blood volumes and low platelet counts enhances its utility.
  • Further development and standardization can expand its role in diagnosing and monitoring platelet disorders.