CLINICAL SIGNIFICANCE LEVELS OF C-REACTIVE PROTEIN AND CERULOPLASMIN IN PATIENTS WITH ISCHEMIC HEART DISEASE
Insights
This study found that measuring ceruloplasmin and C-reactive protein (CRP) levels together can predict outcomes in coronary heart disease patients. Lower ceruloplasmin and higher CRP indicate a worse prognosis, highlighting their role in assessing vascular inflammation.
Area of Science:
- Cardiovascular Medicine
- Biomarker Research
- Inflammation Studies
Background:
- Coronary heart disease (CHD) poses significant health risks, necessitating improved diagnostic and prognostic tools.
- Ceruloplasmin and C-reactive protein (CRP) are potential biomarkers associated with cardiovascular disease.
- Understanding the interplay of these markers may offer insights into disease activity and patient outcomes.
Purpose of the Study:
- To investigate the relationship between ceruloplasmin and CRP levels in patients with coronary heart disease.
- To assess the utility of these biomarkers in diagnosing CHD and predicting the development of complications.
- To explore their potential role in evaluating the activity of vascular inflammation.
Main Methods:
- A cohort of 117 patients with ischemic heart disease (age 39-80) was studied.
- Patient prognosis was assessed over a two-year observation period.
- Levels of ceruloplasmin and C-reactive protein (CRP) were measured and analyzed.
Main Results:
- A significant inverse relationship was identified between ceruloplasmin and CRP levels.
- Patients with high ceruloplasmin (>0.2 g/L) and low CRP (<6.0 mg/L) exhibited significantly better survival rates.
- Conversely, low ceruloplasmin (<0.2 g/L) and high CRP (>6.0 mg/L) were associated with a poorer prognosis (p < 0.05).
Conclusions:
- Combined measurement of ceruloplasmin and highly sensitive CRP offers a valuable method for assessing vascular inflammation activity in CHD patients.
- This combined approach can aid in predicting the development of acute coronary events.
- These biomarkers hold promise for improving risk stratification and personalized management strategies in cardiovascular disease.
Introduction:
The study examined the relationship of levels of ceruloplasmin and CRP in patients with coronary heart disease and assessed the possibility of their use for diagnosis and prediction of developing complications.
Aim:
The study investigated the relationship of levels of ceruloplasmin and CRP in patients with coronary heart disease and their potential use in the diagnosis and prediction of complications.
Materials And Methods:
Examined 117 patients with ischemic heart disease at the age of 39 to 80 years (median age + 13.9 61.7 years), among them 56 were women and 61 men. Assessment of prognosis in patients with ischemic heart disease was conducted based on the two-year observation.
Results:
The reverse relationship between the levels of ceruloplasmin and CRP was identified. When comparing the survival curves without adverse events using the log-rank analysis in patients with levels of CPU of more than 0.2 grams per liter and CRP of less than 6.0 mg/l, the prognosis was significantly better than in patients with simultaneously detected low levels of the CPU (less than 0.2 g/l) and high levels of CRP (more than 6.0 mg/l) in the blood (p < 0.05), CONCLUSIONS: Highly sensitive measurement method of levels of c-reactive protein in patients with coronary heart disease combined with measurement of levels of ceruloplasmin, gives an opportunity to assess the activity of vascular inflammation that can be used to predict the development of acute coronary events.
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