CLINICAL SIGNIFICANCE LEVELS OF C-REACTIVE PROTEIN AND CERULOPLASMIN IN PATIENTS WITH ISCHEMIC HEART DISEASE

Area of Science:

• Cardiovascular Medicine
• Biomarker Research
• Inflammation Studies

Background:

• Coronary heart disease (CHD) poses significant health risks, necessitating improved diagnostic and prognostic tools.
• Ceruloplasmin and C-reactive protein (CRP) are potential biomarkers associated with cardiovascular disease.
• Understanding the interplay of these markers may offer insights into disease activity and patient outcomes.

Purpose of the Study:

• To investigate the relationship between ceruloplasmin and CRP levels in patients with coronary heart disease.
• To assess the utility of these biomarkers in diagnosing CHD and predicting the development of complications.
• To explore their potential role in evaluating the activity of vascular inflammation.

Main Methods:

• A cohort of 117 patients with ischemic heart disease (age 39-80) was studied.
• Patient prognosis was assessed over a two-year observation period.
• Levels of ceruloplasmin and C-reactive protein (CRP) were measured and analyzed.

Main Results:

• A significant inverse relationship was identified between ceruloplasmin and CRP levels.
• Patients with high ceruloplasmin (>0.2 g/L) and low CRP (<6.0 mg/L) exhibited significantly better survival rates.
• Conversely, low ceruloplasmin (<0.2 g/L) and high CRP (>6.0 mg/L) were associated with a poorer prognosis (p < 0.05).

Conclusions:

• Combined measurement of ceruloplasmin and highly sensitive CRP offers a valuable method for assessing vascular inflammation activity in CHD patients.
• This combined approach can aid in predicting the development of acute coronary events.
• These biomarkers hold promise for improving risk stratification and personalized management strategies in cardiovascular disease.