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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Brain Imaging01:14

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Related Experiment Video

Updated: Mar 25, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

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A novel method for evaluating brain function and microstructural changes in Parkinson's disease.

Ming-Fang Jiang1, Feng Shi2, Guang-Ming Niu3

  • 1Department of Neurology, General Hospital of PLA, Beijing, China.

Neural Regeneration Research
|February 19, 2016
PubMed
Summary
This summary is machine-generated.

Parkinson's disease causes brain damage, particularly in the substantia nigra and basal ganglia. This microstructural damage correlates with disease severity, depression, and cognitive decline, as shown by diffusion tensor imaging.

Keywords:
basal gangliacognitive dysfunctiondepressiondiffusion tensor imagingfunctional magnetic resonance imagingnerve regeneration; Parkinson's diseaseneural regenerationsubstantia nigratract-based spatial statistical analysis

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Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting motor function.
  • The underlying histopathological changes and their correlation with non-motor symptoms like depression and cognitive dysfunction require further elucidation.

Purpose of the Study:

  • To investigate microstructural brain damage in Parkinson's disease patients using advanced neuroimaging techniques.
  • To correlate the extent of neuronal damage with disease severity, depression, and cognitive impairment.

Main Methods:

  • Diffusion Tensor Imaging (DTI) was employed to assess white matter integrity.
  • Tract-Based Spatial Statistics (TBSS) was utilized for detailed analysis of microstructural changes across the brain.

Main Results:

  • Significant neuronal damage was identified in the substantia nigra and putamen of PD patients.
  • Damage to the substantia nigra correlated with worsening motor symptoms, confirming its central role in PD.
  • Microstructural damage in the putamen, caudate nucleus, and frontal lobe was associated with depression.
  • White matter tract damage correlated with cognitive disorders and depression.

Conclusions:

  • DTI and TBSS are effective tools for studying brain function and microstructural changes in Parkinson's disease.
  • Novel findings elucidate the histopathological basis of cognitive dysfunction and depression in PD, highlighting the impact on basal ganglia and white matter tracts.