Related Experiment Video
Updated: Mar 25, 2026
10:16
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
8.1K
Improved delivery of poorly soluble compounds using nanoparticle technology: a review
Sandeep Kalepu1, Vijaykumar Nekkanti2
1Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India. kalepu_sandeep3@yahoo.co.in.
Drug Delivery and Translational Research
|February 20, 2016
Summary
Formulating drug nanoparticles enhances solubility and bioavailability for poorly soluble drugs. This review details scalable manufacturing and characterization of drug nanoparticles for improved drug delivery.
Area of Science:
- Pharmaceutical Science
- Drug Delivery Systems
Background:
- Many new drug molecules face developmental hurdles due to limited aqueous solubility, impacting bioavailability.
- Poor solubility is a significant challenge in drug development, necessitating advanced formulation strategies.
Purpose of the Study:
- To review the formulation of drug nanoparticles for improved solubility and dissolution.
- To highlight nanonization as a key technology for developing poorly soluble drugs.
- To discuss scalable manufacturing approaches and characterization techniques for drug nanoparticles.
Main Methods:
- Review of nanonization principles and applications in drug formulation.
- Discussion of scalable manufacturing techniques for drug nanoparticles.
- Overview of advanced characterization methods for evaluating drug nanoparticles.
Main Results:
- Nanonization offers a versatile solution for enhancing solubility and bioavailability of poorly soluble drugs.
- A simple and scalable approach for manufacturing drug nanoparticles is presented.
- Latest characterization techniques for assessing drug nanoparticles are discussed.
Conclusions:
- Drug nanoparticulate formulation is a broadly applicable platform technology.
- This approach effectively addresses challenges associated with poor aqueous solubility.
- Enhanced solubility and bioavailability can be achieved through drug nanonization.
Related Concept Videos
01:16Bioavailability Enhancement: Drug Solubility Enhancement
424
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
424
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
2.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.0K
01:27Bioavailability Enhancement: Drug Permeability Enhancement
299
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
299
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
107
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
107
01:24Modified-Release Drug Delivery Systems: Site-Targeted
94
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
94
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
321
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
321