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Updated: Mar 25, 2026

Dissecting Mechanoenzymatic Properties of Processive Myosins with Ultrafast Force-Clamp Spectroscopy
Published on: July 1, 2021
Passive trapping of rigid rods due to conformation-dependent electrophoretic mobility
Harsh Pandey1, Sylvia A Szafran1, Patrick T Underhill1
1Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th St, Troy, New York 12180, USA. underhill@rpi.edu.
Abstract:
We present computer simulations of a rigid rod in a combination of an extensional fluid flow and extensional electric field. The electrophoretic mobility of the rod is different parallel or perpendicular to the rod. The dependence of the mobility on the conformation (orientation) leads to a new phenomenon where the rods can be passively trapped in all directions at the stagnation point. This contrasts with the behavior in either fluid flow or electric field alone, in which an object can be pushed towards the stagnation point along some directions but is pushed away in others. We have determined the state space where trapping occurs and have developed a model that describes the strength of trapping when it does occur. This new phenomenon could be used in the future to separate objects based on a coupling between their mobility and ability to be oriented.
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