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Updated: Mar 25, 2026

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Genomic Variations Affecting Biological Effects of Statins

Alessandra Bitto1, Giovanni Pallio, Sonia Messina

  • 1Department of Clinical and Experimental Medicine, Section of Pharmacology, Torre Biologica 5th floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125, Messina, Italy. fsquadrito@unime.it.

Current Drug Metabolism
|February 20, 2016
PubMed
Summary

Genetic variations influence how patients respond to statin therapy for cholesterol management. While many gene polymorphisms are linked to statin effectiveness, current evidence does not support routine pharmacogenomic testing before treatment.

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