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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
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Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions
Aysha Ali1, Pushpavalli Mohan2, Hana Kareem3
1Associate Professor, Department of Pathology, Karuna Medical College , Palakkad, Kerala, India .
Journal of Clinical and Diagnostic Research : JCDR
|February 20, 2016
Summary
Recurrent abortions in Indian women are significantly linked to elevated Factor VIII levels and shortened activated partial thromboplastin time (APTT). Shortened APTT also emerged as an independent risk factor for pregnancy loss.
Area of Science:
- Reproductive Medicine
- Hematology
- Thrombophilia
Background:
- Thrombotic disorders are associated with recurrent pregnancy loss.
- Elevated Factor VIII and shortened activated partial thromboplastin time (APTT) are potential risk factors for recurrent miscarriage.
- Limited research exists on these associations in the Indian population.
Purpose of the Study:
- To investigate the association between elevated Factor VIII levels, shortened APTT, and recurrent abortions in Indian women.
- To determine if shortened APTT is an independent risk factor for recurrent abortions.
Main Methods:
- A case-control study included 68 women with recurrent abortions and 68 controls.
- Exclusion criteria included other known causes of pregnancy loss.
- Activated partial thromboplastin time (APTT) and Factor VIII assays were performed.
Main Results:
- 36.4% of cases had elevated Factor VIII levels; 27.3% had shortened APTT.
- 18% of cases showed both elevated Factor VIII and shortened APTT.
- Control subjects did not exhibit elevated Factor VIII or shortened APTT (p<0.05).
Conclusions:
- Significant association found between recurrent abortions and elevated Factor VIII levels and shortened APTT.
- Shortened APTT is identified as an independent risk factor for recurrent abortions.
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