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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

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Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
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Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Updated: Mar 25, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
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microRNAs as Biomarker in Depression Pathogenesis.

Yogesh Dwivedi1

  • 1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, USA.

Annals of Psychiatry and Mental Health
|February 20, 2016
PubMed
Summary

MicroRNAs (miRNAs) show promise as biomarkers for major depressive disorder (MDD) and treatment response. Further research into miRNAs could lead to targeted therapies and improved patient outcomes for depression.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Major depressive disorder (MDD) presents significant challenges due to high relapse rates and limited treatment efficacy.
  • Understanding MDD pathophysiology is crucial for developing effective interventions and identifying predictive biomarkers.
  • MicroRNAs (miRNAs) are small non-coding RNAs involved in gene expression regulation, with emerging roles in neurological disorders.

Purpose of the Study:

  • To review current research on the role of miRNAs in the pathophysiology of MDD.
  • To explore the potential of miRNAs as biomarkers for predicting MDD treatment response.
  • To discuss the implications of miRNA research for developing targeted depression therapies.

Main Methods:

  • Systematic review of recent scientific literature on miRNAs and MDD.
Keywords:
BiomarkerMajor depressionPlasmaStressmicroRNA

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  • Analysis of studies investigating miRNA involvement in synaptic plasticity, neurogenesis, and stress response.
  • Evaluation of research on miRNAs as potential biomarkers for MDD prognosis and treatment outcomes.

    • Main Results:

    • Emerging evidence suggests miRNAs play a direct role in the development of depression phenotypes.
    • miRNAs are implicated in key processes affected in MDD, including synaptic plasticity and stress response.
    • Studies indicate miRNAs may serve as predictive biomarkers for treatment response in MDD patients.

    Conclusions:

    • MicroRNAs represent a promising area of research for understanding MDD pathogenesis.
    • miRNAs hold potential as valuable biomarkers for personalized treatment strategies in major depressive disorder.
    • Further investigation into miRNAs could facilitate the development of novel, targeted therapies for depression.