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Updated: Mar 25, 2026

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry
David O'Hagan1, Robert J Young2
1School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK. do1@st-andrews.ac.uk.
Abstract:
Polar exploration: Recently, Linclau and co-workers disclosed a straightforward (19)F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.
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