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Histoplasmosis.

Lawrence J Wheat1, Marwan M Azar2, Nathan C Bahr3

  • 1MiraVista Diagnostics, 4705 Decatur Boulevard, Indianapolis, IN 46241, USA.

Infectious Disease Clinics of North America
|February 22, 2016
PubMed
Summary
This summary is machine-generated.

Histoplasmosis, a fungal infection, can occur globally and mimic pneumonia. Prompt diagnosis using various assays and effective treatment are crucial, even for immunocompromised individuals.

Keywords:
AntibodyAntigenCentral nervous systemDisseminatedHistoplasmaHistoplasmosisPulmonarySerology

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Histoplasmosis is endemic in the Americas but presents globally.
  • Pulmonary histoplasmosis symptoms and radiographic findings often resemble community-acquired pneumonia.
  • It can affect both immunocompetent and immunocompromised individuals.

Purpose of the Study:

  • To highlight the global relevance of histoplasmosis.
  • To emphasize the diagnostic challenges and methods for histoplasmosis.
  • To underscore the effectiveness of treatment for histoplasmosis.

Main Methods:

  • Review of clinical presentations and diagnostic approaches for histoplasmosis.
  • Discussion of mycologic and non-culture-based diagnostic assays.
  • Evaluation of treatment efficacy in various patient populations.

Main Results:

  • Histoplasmosis frequently presents as pulmonary illness, often misdiagnosed.
  • A combination of diagnostic assays can confirm histoplasmosis within days to a week.
  • Effective treatment options exist, even for immunocompromised patients.

Conclusions:

  • Histoplasmosis should be considered in patients with unexplained systemic or pulmonary conditions.
  • Timely diagnosis through appropriate assays is key.
  • Effective and accessible treatments are available for histoplasmosis.