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Methotrexate-induced sudden fatal pulmonary reaction
Cancer
|October 1, 1977
Summary
A teenage patient with acute lymphocytic leukemia experienced fatal pulmonary edema after starting oral methotrexate. This rare reaction, possibly due to prior intrathecal methotrexate sensitization, highlights potential drug-induced lung toxicity.
Area of Science:
- Oncology
- Pulmonology
- Pharmacology
Background:
- Acute lymphocytic leukemia (ALL) treatment involves chemotherapy agents like methotrexate and cyclophosphamide.
- Methotrexate can cause pulmonary toxicity, typically after prolonged administration.
- Intrathecal chemotherapy is used to prevent or treat central nervous system leukemia.