Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections
Sylvain Goutelle1, Sandrine Roux2, Marie-Claude Gagnieu3
1Hospices Civils de Lyon, Groupement Hospitalier de Gériatrie, Service Pharmaceutique, Lyon, France ISPB, Faculté de Pharmacie de Lyon, Université Lyon 1, Lyon, France UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive, Université Lyon 1, Villeurbanne, France sylvain.goutelle@chu-lyon.fr.
Abstract:
The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.
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