Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.9K
Microbiome of the Eye01:22

Microbiome of the Eye

24
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
24
Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

925
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
925
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Granuloma annulare: An updated review of epidemiology, molecular pathogenesis, and management.

Journal of the American Academy of Dermatology·2026
Same author

Improvement of recalcitrant Hailey-Hailey disease (<i>ATP2C1</i>-nonsyndromic epidermal differentiation disorder) with topical ruxolitinib 1.5% cream.

Skin health and disease·2026
Same author

Presentation, Diagnosis, and Treatment of Cutaneous Crohn Disease.

JAMA dermatology·2026
Same author

Leukocytoclastic vasculitis and necrobiotic pulmonary nodules in endoscopic remission of ulcerative colitis.

JPGN reports·2026
Same author

An Update on Inflammatory Dermatopathology.

Dermatologic clinics·2026
Same author

Xanthelasma-like eyelid plaque secondary to periocular <i>Demodex</i> infestation with granulomatous dermatitis.

Orbit (Amsterdam, Netherlands)·2026

Related Experiment Video

Updated: Mar 25, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Multisystem diseases affecting the skin and eye.

Karolyn A Wanat1, Benjamin Kim2, Misha Rosenbach3

  • 1Department of Dermatology, University of Iowa Carver College of Medicine, Des Moines, IA.

Clinics in Dermatology
|February 24, 2016
PubMed
Summary

Multisystem diseases often impact the skin and eyes, requiring prompt diagnosis and treatment. Recognizing mucocutaneous and ophthalmologic signs is key to managing these severe systemic conditions.

More Related Videos

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

878
A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

12.2K

Related Experiment Videos

Last Updated: Mar 25, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K
Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

878
A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

12.2K

Area of Science:

  • Ophthalmology
  • Dermatology
  • Rheumatology
  • Internal Medicine

Background:

  • Multisystem diseases frequently present with ocular and cutaneous manifestations.
  • Skin and eye involvement can be primary indicators of systemic illness or complications of existing disease.
  • Early recognition and management are crucial for preventing severe sequelae.

Purpose of the Study:

  • To review multisystem diseases with significant mucocutaneous and ophthalmologic involvement.
  • To emphasize the importance of recognizing cutaneous and ocular signs for diagnosis and management.
  • To guide physicians in evaluating and treating patients with these complex conditions.

Main Methods:

  • Review of literature on specific multisystem diseases.
  • Focus on the interplay between systemic disease and its effects on skin and eyes.
  • Discussion of diagnostic and therapeutic strategies.

Main Results:

  • Identified key multisystem diseases including reactive arthritis, sarcoidosis, Behçet disease, and vasculitides.
  • Highlighted the diagnostic value of mucocutaneous and ophthalmologic findings.
  • Stressed the critical role of managing skin and eye symptoms to prevent long-term morbidity.

Conclusions:

  • A comprehensive understanding of mucocutaneous and ocular manifestations is essential for diagnosing and managing multisystem diseases.
  • Integrated management of skin and eye symptoms is vital for patient outcomes.
  • Physician awareness of these presentations improves patient evaluation and treatment efficacy.