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Alopecia in Systemic Amyloidosis: Trichoscopic-Pathologic Correlation.

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Alopecia linked to systemic amyloidosis is rare. Key trichoscopic findings include a distinctive salmon-colored halo around hair follicles, indicating amyloid deposits.

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Area of Science:

  • Dermatology
  • Pathology
  • Trichology

Background:

  • Systemic amyloidosis is a rare condition.
  • Alopecia is an uncommon manifestation of systemic amyloidosis, typically presenting as diffuse nonscarring alopecia.
  • Previous reports describe limited cases, necessitating further investigation into its specific dermatoscopic features.

Observation:

  • This study reports trichoscopic findings in patients with alopecia secondary to systemic amyloidosis.
  • The most striking observation was a salmon-colored halo surrounding follicular ostia, measuring 0.3-1 mm in diameter.
  • Additional observed features included broken hairs and black dots.

Findings:

  • The prominent salmon-colored halo was pathologically correlated with perifollicular amyloid deposition.
  • Horizontal sections revealed preserved sebaceous glands.
  • These findings support a nonscarring pattern of alopecia in this context.

Implications:

  • Trichoscopy can aid in diagnosing alopecia associated with systemic amyloidosis.
  • The salmon-colored halo serves as a potential diagnostic marker.
  • Understanding these features can improve clinical recognition and management of this rare condition.