(18)F-FDG PET/CT in multicentric Castleman disease: a case report

Area of Science:

• Oncology
• Internal Medicine
• Pathology

Background:

• Castleman disease (CD) is a rare lymphoproliferative disorder.
• It presents as single-centric or multicentric (MCD) forms, with MCD being rare and often misdiagnosed due to non-specific symptoms.

Observation:

• A case report of a 43-year-old male with suspected MCD.
• (18)F-FDG PET/CT imaging revealed increased uptake in multiple lymph nodes, spleen, and bone marrow.
• A biopsy of a right inguinal lymph node confirmed Castleman disease.

Findings:

• The study confirms a diagnosis of Multicentric Castleman disease.
• Diagnostic imaging using (18)F-FDG PET/CT showed characteristic patterns of metabolic activity.
• Histopathological examination of lymph node biopsy provided definitive diagnosis.

Implications:

• This case underscores the importance of considering MCD in patients with unexplained lymphadenopathy.
• (18)F-FDG PET/CT can be a valuable tool in the diagnostic workup of MCD.
• Early and accurate diagnosis of MCD is crucial for timely management and improved patient outcomes.