Related Experiment Video
Updated: Mar 25, 2026

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
Published on: February 28, 2025
Antiglycation Activity of Iridoids and Their Food Sources
Brett J West1, Akemi Uwaya2, Fumiyuki Isami2
1Research and Development, Morinda, Inc., 737 East 1180 South, American Fork, UT 84003, USA.
Dietary iridoids show potential in combating advanced glycation end products (AGEs). Studies indicate iridoid consumption may reduce AGE accumulation, suggesting an antiaging strategy.
Area of Science:
- Nutritional Biochemistry
- Phytochemistry
- Aging Research
Background:
- Advanced glycation end products (AGEs) are implicated in aging and chronic diseases.
- Dietary phytochemicals, such as iridoids, are being investigated for their potential health benefits.
- Iridoids are naturally occurring compounds found in various food sources.
Purpose of the Study:
- To investigate the anti-AGE potential of food-derived iridoids.
- To evaluate the in vitro antiglycation activity of specific iridoids.
- To assess the effect of iridoid consumption on AGE accumulation in humans.
Main Methods:
- In vitro antiglycation assay using bovine serum albumin, glucose, and fructose.
- An 8-week open-label pilot study with 34 overweight adults measuring skin autofluorescence.
- A cross-sectional population study with 3913 participants analyzing iridoid intake and AGEs.
Main Results:
- Deacetylasperulosidic acid and loganic acid demonstrated concentration-dependent inhibition of glycation in vitro.
- Pilot study participants showed a significant decrease in average skin autofluorescence.
- Population study revealed a significant inverse relationship between iridoid intake and AGE accumulation.
Conclusions:
- Dietary iridoids possess antiglycation properties.
- Consumption of iridoid-rich foods may reduce AGE accumulation in humans.
- Iridoid intake could serve as a viable antiaging strategy.
More Related Videos
07:40Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Related Concept Videos
Cancer Prevention
Some...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Radical Autoxidation
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...