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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
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Related Experiment Video

Updated: Mar 25, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Sepsis Causing Acquired Protein C and Protein S Deficiency.

Arun Kannan1, Sweta Chandra1, Jose Lizcano1

  • 1Canton Medical Education Foundation, Canton OH, USA.

JNMA; Journal of the Nepal Medical Association
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

Sepsis can cause protein C deficiency, leading to dangerous warfarin-induced skin necrosis. This case highlights the need to consider sepsis as a cause of this rare complication.

Keywords:
protein C; Protein S; sepsis; skin necrosis; warfarin.

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Area of Science:

  • Medical Complications
  • Hematology
  • Dermatology

Background:

  • Warfarin-induced skin necrosis is a severe complication linked to protein C deficiency.
  • Acquired protein C deficiency is typically seen during initial warfarin therapy without adequate anticoagulation bridging.

Observation:

  • A 43-year-old female on chronic warfarin for antiphospholipid syndrome developed skin necrosis.
  • She was admitted for ischemic stroke, had warfarin temporarily stopped due to thrombocytopenia, and restarted upon discharge.
  • She later presented with septic shock from pneumonia, exhibiting multiple necrotic skin lesions.

Findings:

  • Sepsis was identified as an unusual cause of acquired protein C deficiency in this patient.
  • The deficiency led to warfarin-induced skin necrosis despite chronic warfarin use.

Implications:

  • Recognizing sepsis as a potential cause of acquired protein C deficiency is crucial for managing patients on warfarin.
  • This case underscores the importance of comprehensive patient assessment and considering non-standard causes for complications.