Related Experiment Video
Updated: Mar 25, 2026
07:30
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
10.7K
Sepsis Causing Acquired Protein C and Protein S Deficiency
Arun Kannan1, Sweta Chandra1, Jose Lizcano1
1Canton Medical Education Foundation, Canton OH, USA.
JNMA; Journal of the Nepal Medical Association
|February 25, 2016
Summary
Sepsis can cause protein C deficiency, leading to dangerous warfarin-induced skin necrosis. This case highlights the need to consider sepsis as a cause of this rare complication.
Area of Science:
- Medical Complications
- Hematology
- Dermatology
Background:
- Warfarin-induced skin necrosis is a severe complication linked to protein C deficiency.
- Acquired protein C deficiency is typically seen during initial warfarin therapy without adequate anticoagulation bridging.
Observation:
- A 43-year-old female on chronic warfarin for antiphospholipid syndrome developed skin necrosis.
- She was admitted for ischemic stroke, had warfarin temporarily stopped due to thrombocytopenia, and restarted upon discharge.
- She later presented with septic shock from pneumonia, exhibiting multiple necrotic skin lesions.
Findings:
- Sepsis was identified as an unusual cause of acquired protein C deficiency in this patient.
- The deficiency led to warfarin-induced skin necrosis despite chronic warfarin use.
Implications:
- Recognizing sepsis as a potential cause of acquired protein C deficiency is crucial for managing patients on warfarin.
- This case underscores the importance of comprehensive patient assessment and considering non-standard causes for complications.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
950
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
950
01:25Immunodeficiency Diseases
2.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.8K
01:27Complement System
12.3K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
12.3K
01:29Staphylococcal Skin Infections
33
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
33
01:21Overview of Protein Metabolism
4.6K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
4.6K
01:24Disorders of Hemostasis
2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.7K