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Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317

Hirozumi Toyama1, Shoko Sato2, Hitoshi Shirakawa3

  • 1Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032 Tokyo, Japan.

Bioorganic & Medicinal Chemistry Letters
|February 25, 2016
PubMed

Keywords:
Nuclear receptorPregnane X receptor (PXR)Retinoic acid receptor-related orphan receptor (ROR)Sila-substitutionSilanolT0901317

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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