Related Experiment Video

Updated: Mar 25, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

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Ocular Toxicity of Tyrosine Kinase Inhibitors

Mary Elizabeth Davis1

  • 1Department of Ambulatory Nursing, Memorial Sloan-Kettering Cancer Center, New York, NY.

Oncology Nursing Forum
|February 25, 2016
PubMed
Abstract

Insights

Tyrosine kinase inhibitors (TKIs) used in cancer therapy can cause serious eye side effects. Oncology nurses play a crucial role in managing these ocular toxicities for improved patient care.

Area of Science:

  • Oncology
  • Ophthalmology
  • Pharmacology

Background:

  • Tyrosine kinase inhibitors (TKIs) are increasingly utilized in targeted cancer therapies.
  • Ocular side effects associated with TKIs are a growing concern in patient care.

Purpose of the Study:

  • To review common tyrosine kinase inhibitors.
  • To outline their associated ocular side effects.
  • To discuss management strategies for these toxicities.

Main Methods:

  • A comprehensive literature search was performed.
  • Databases searched include CINAHL®, PubMed, and Cochrane.
  • Articles published since 2004 were included.

Main Results:

  • Tyrosine kinase inhibitors can lead to significant ocular toxicity.
  • Understanding the pathogenesis of ocular pathology is complex.

Conclusions:

  • Oncology nurses must be aware of potential ocular toxicities from TKIs.
  • Nursing assessment, patient education, and early detection are vital for managing TKI-induced ocular toxicity.
  • Knowledge of risk factors and etiology aids in enhancing patient care and management.
Keywords:
ocularophthalmologytargeted therapytoxicitytyrosine kinase inhibitors

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