Chemotherapy-Induced Peripheral Neuropathy: Assessment and Treatment Strategies for Advanced Practice Providers.

Area of Science:

• Oncology
• Neuroscience
• Pharmacology

Background:

• Chemotherapy-induced peripheral neuropathy (CIPN) is a significant adverse event in cancer treatment.
• CIPN can manifest as chronic pain and sensory disturbances, persisting long after therapy cessation.

Purpose of the Study:

• To investigate the underlying mechanisms and long-term consequences of CIPN.
• To identify potential therapeutic targets for mitigating CIPN symptoms.

Main Methods:

• Review of preclinical and clinical studies on CIPN.
• Analysis of neurophysiological and patient-reported outcome data.

Main Results:

• CIPN affects a substantial proportion of patients undergoing specific chemotherapies.
• Persistent neuropathic pain and altered sensation are common sequelae.

Conclusions:

• Understanding CIPN's pathophysiology is crucial for developing effective interventions.
• Managing chronic CIPN requires a multidisciplinary approach to improve patient outcomes.