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Estrogen replacement therapy: an overview
1Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
American Journal of Obstetrics and Gynecology
|December 1, 1989
Abstract:
Levels of circulating estrogen fall during the perimenopausal period, resulting in changes in the postmenopausal woman's genitourinary tract, central nervous and cardiovascular systems, skin, and bone. Exogenous estrogen minimizes the benign symptoms and prevents the increased incidence of osteoporosis and atherosclerotic heart disease that accompany estrogen deficiency. Thus to avoid the recognized problems of estrogen deficiency, nearly all women should begin a lifelong course of estrogen replacement therapy during the perimenopausal period.