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Updated: Aug 8, 2026
10:24
Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
Published on: May 9, 2016
Types of collagen in breast capsules
W R Marshall1, M Godfrey, D W Hollister
1Department of Surgery, Oregon Health Sciences University, Portland.
Annals of Plastic Surgery
|November 1, 1989
Summary
Collagen analysis of surgical capsule tissue revealed Type I collagen as predominant. Capsule collagen composition correlated with age, similar to cutaneous scar tissue.
Area of Science:
- Biomaterials Science
- Connective Tissue Research
- Surgical Pathology
Background:
- Capsular contracture is a complication of silicone implants.
- The extracellular matrix, particularly collagen, plays a role in capsule formation.
Purpose of the Study:
- To analyze the collagen content of capsules surrounding surgically implanted silicone.
- To investigate the relationship between collagen composition, capsule classification, and capsule age.
Main Methods:
- Analysis of biopsied capsule specimens (n=18) surrounding silicone implants.
- Slab gel electrophoresis to determine collagen types and concentrations.
- Comparison with clinically assessed capsule classifications and patient age.
Main Results:
- Type I collagen was the predominant collagen type in all analyzed capsules.
- Type III and Type V collagens were present in lesser and small amounts, respectively.
- Collagen composition showed a correlation with capsule age but not with clinical capsule classification or tissue expander capsules.
Conclusions:
- The collagen composition of capsules around silicone implants is similar to that of cutaneous scar tissue.
- Capsule age is a significant factor influencing collagen content.
- Further research may elucidate the role of specific collagen types in capsular contracture.
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