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Antifungal Lock Therapy with Liposomal Amphotericin B: A Prospective Trial

William McGhee1, Marian G Michaels2, Judith M Martin2

  • 1Department of Pharmacy, Children's Hospital of Pittsburgh Department of Pharmacy and Therapeutics, University of Pittsburgh Pharmacy School.

Journal of the Pediatric Infectious Diseases Society
|February 25, 2016
PubMed

Keywords:
Central linefungal infectionsliposomal Amphotericin Bliposomal lock therapy

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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