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[X-ray diffractometry in the analysis of drugs and pharmaceutical forms]
Bollettino Chimico Farmaceutico
|May 1, 1989
Summary
X-ray diffraction is crucial for characterizing solid drug substances, identifying crystalline and amorphous forms, and analyzing drug mixtures and formulations. This technique provides essential data for pharmaceutical development and quality control.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Analytical Chemistry
Context:
- Solid drug substance characterization is vital in the pharmaceutical industry.
- X-ray diffraction (XRD) is a primary analytical tool for this purpose.
- XRD methods include powder and single crystal diffraction.
Purpose:
- To detail the pharmaceutical applications of X-ray diffraction.
- To explain the principles of X-ray interaction with solid matter.
- To illustrate the use of XRD in characterizing various drug forms and systems.
Summary:
- X-ray powder diffraction (XRPD) identifies crystalline/amorphous compounds, polymorphs, and drug-carrier systems (e.g., solid dispersions, solid solutions).
- XRPD enables qualitative and quantitative analysis of drug mixtures and dosage forms.
- Single crystal XRD determines unit cell parameters and elucidates crystal/molecular structures.
Impact:
- Facilitates accurate identification and characterization of solid drug substances.
- Supports the development of stable and effective pharmaceutical formulations.
- Enhances quality control throughout drug development and manufacturing.