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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Unusual Presentation of Dengue Fever: A child with acute myocarditis
Moaz Aslam1, Numra A Aleem1, Mohammad F Zahid1
1Medical College, Aga Khan University, Karachi, Pakistan.
Insights
Dengue fever can cause myocarditis, a serious heart complication. Early detection and supportive care are crucial for a child
Area of Science:
- Pediatrics
- Infectious Diseases
- Cardiology
Background:
- Dengue fever (DF) is a common viral illness.
- While typically self-limiting, DF can lead to severe organ complications.
- Myocarditis is a recognized but often overlooked complication of DF.
Purpose of the Study:
- To report a case of dengue-associated myocarditis in a child.
- To emphasize the importance of cardiac monitoring in DF patients with cardiac symptoms.
- To highlight the need for early diagnosis and management of myocarditis in dengue.
Main Methods:
- A case report of a pediatric patient diagnosed with Dengue Fever.
- Clinical presentation included high-grade fever, malaise, and epigastric pain.
- Cardiac investigations revealed myocardial damage, confirmed by echocardiography and cardiac enzymes.
Main Results:
- The child presented with symptoms suggestive of dengue fever and subsequent cardiac involvement.
- Diagnostic assays confirmed Dengue Fever (DF) and immunoglobulin M.
- Supportive care and inotropic agents led to the normalization of cardiac function and enzyme levels.
Conclusions:
- Myocarditis is a significant complication of Dengue Fever that requires prompt recognition.
- Pediatricians and clinicians should maintain a high index of suspicion for cardiac involvement in DF patients.
- Early supportive management is critical for favorable outcomes in dengue-associated myocarditis.
Abstract:
Dengue fever (DF) is an acute febrile illness that follows a self-limiting course. However, some patients suffer from complications, including myocarditis, due to the involvement of other organs. A child presented at the Aga Khan University Hospital in Karachi, Pakistan, in June 2013 with a high-grade fever, malaise and epigastric pain radiating to the chest. Positive DF antigen and immunoglobulin M assays confirmed the diagnosis of DF. Persistent bradycardia with low blood pressure led to further cardiac investigations which showed a decreased ejection fraction and raised serum cardiac enzymes, indicating myocardial damage. With supportive care and use of inotropes, the spontaneous normalisation of cardiac enzyme levels and ejection fraction was observed. The child was discharged five days after admission. This case highlights the importance of identifying myocarditis in DF patients suffering from cardiac symptoms that are not explained by other potential aetiologies. Awareness, early suspicion and supportive care are essential to ensure favourable outcomes.
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