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Updated: May 28, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

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Published on: July 28, 2022

ABO Incongruency Increases Risk for Necrotizing Enterocolitis in Preterm Neonates.

Jeremy A Sandgren1, Numra A Aleem1, J Brooks Jackson2

  • 1Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

ABO incongruent preterm neonates, born to mothers with type O blood, showed increased risks for necrotizing enterocolitis and pulmonary hypertension. Further research is needed to confirm these findings in the preterm population.

Keywords:
ABO blood groupABO incongruencyNecrotizing enterocolitisNeonatalPrematurity

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Area of Science:

  • Neonatalogy
  • Immunology
  • Perinatal Medicine

Background:

  • Preterm neonates face significant health risks, with inflammation playing a key role in pathologies.
  • ABO incongruency, where maternal and neonatal blood types differ, can lead to antibody-mediated complications.
  • This study focuses on ABO incongruency in preterm infants born to mothers with type O blood.

Purpose of the Study:

  • To investigate if preterm neonates with ABO incongruent blood types experience higher rates of complications compared to ABO congruent neonates.
  • To examine the association between ABO incongruency and specific neonatal morbidities in preterm infants.
  • To test the hypothesis that ABO incongruent preterm neonates have increased neonatal morbidity.

Main Methods:

  • Retrospective cohort study of 371 preterm neonates (21 0/7–32 6/7 weeks gestation) born to mothers with type O blood.
  • Neonates were categorized as ABO incongruent or congruent and by gestational age groups (22-26 and 27-32 weeks).
  • Outcomes assessed included bronchopulmonary dysplasia, pulmonary hypertension, PDA, NEC, RBC transfusions, IVH, periventricular leukomalacia, and survival.

Main Results:

  • ABO incongruent neonates (27-32 weeks gestation) had a higher likelihood of developing necrotizing enterocolitis (NEC).
  • A trend towards increased early pulmonary hypertension was observed in ABO incongruent neonates (27-32 weeks gestation).
  • Trends suggested more cardiac dysfunction and severe intraventricular hemorrhage (IVH) in younger preterm infants (22-26 weeks gestation).

Conclusions:

  • ABO incongruency is linked to increased neonatal complications in the preterm population.
  • The study is underpowered to fully assess all neonatal morbidities.
  • Further research is necessary to elucidate the impact of ABO incongruency on neonatal outcomes, especially NEC and pulmonary hypertension.