Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device

Area of Science:

• Oncology
• Minimally Invasive Surgery
• Biomedical Engineering

Background:

• Radiofrequency ablation (RFA) is a minimally invasive therapy for bone metastases.
• A new RFA system with multi-directional and adaptable ablation capabilities is presented.

Purpose of the Study:

• To evaluate a novel RFA system for treating experimental bone metastases.
• To assess the system's ability to create adaptable ablation zones and achieve tumor necrosis.

Main Methods:

• VX-2 tumors were induced in rabbit femurs to create experimental bone metastases.
• Radiofrequency ablation was performed using a bipolar, articulated electrode and an impedance-controlled generator.
• Pre- and post-treatment imaging (X-ray, CT, MRI) and histological examination were conducted.

Main Results:

• All animals developed bone tumors, with osteolytic lesions appearing around 48 days.
• RFA procedures averaged 6 minutes, reaching 55°C, and created a 23mm ablation zone.
• Histopathology confirmed extensive heat necrosis and complete tumor cell eradication within the ablation area.

Conclusions:

• Radiofrequency ablation is a rapidly advancing treatment for bone tumors.
• The novel electrode design allows for ablation tailored to metastasis size and shape.
• Further clinical studies are needed to validate and optimize this RFA system.