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Related Experiment Videos

[Cellular relations during odontogenesis].

J M Meyer, M Fabre, A Staubli

    Journal De Biologie Buccale
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Mouse molar tooth development involves epithelial-mesenchymal interactions. Key findings show basal lamina integrity and fibril deposition, with cell processes interacting closely, and vesicle extrusion during morphogenesis.

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Histology

    Context:

    • Investigating epithelial-mesenchymal interactions is crucial for understanding tooth morphogenesis.
    • Mouse molar development provides a model for studying complex embryonic processes.

    Purpose:

    • To observe epithelial-mesenchymal interactions during mouse molar tooth morphogenesis using electron microscopy.
    • To detail the structural changes and cellular behaviors within the developing tooth germ.

    Summary:

    • Electron microscopy revealed an intact basal lamina from day 10 to 18 of mouse molar development.
    • Aperiodic and periodic fibrils were deposited on the basal lamina, interacting with ectomesenchymal cell processes.
    • Direct cell contacts between odontoblasts and preameloblasts emerged on day 19, with vesicle extrusion observed throughout development.

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    Impact:

    • Provides detailed ultrastructural insights into the dynamic epithelial-mesenchymal interface during tooth formation.
    • Highlights the role of the basal lamina and extracellular matrix in guiding cell behavior.
    • Offers a foundation for further research into the molecular mechanisms governing odontogenesis.