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Hydrocarbon Soluble Recyclable Silylation Reagents and Purification Auxiliaries
Chih-Gang Chao1, Ashley M Leibham1, David E Bergbreiter1
1Department of Chemistry, Texas A&M University , College Station, Texas 77842-3012, United States.
Abstract:
Procedures using heptane-phase-selectively soluble octadecyldimethylsilyl groups to facilitate separations and silyl reagent regeneration are described. These results show that alcohols and alkynes protected by these groups are phase-selectively soluble in hydrocarbon solvents. In a thermomorphic cyclohexane/DMF system, >96% of the silylated alcohols are in the cyclohexane phase, allowing these compounds to be purified by a simple liquid/liquid extraction. Applications of these silylating agents in a Grignard synthesis and Sonogashira reaction are described.
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