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Cannabinoids: Medical implications.

Richard J Schrot1,2, John R Hubbard3,4

  • 1a Veterans' Administration Medical Center, Outpatient Clinic , Tampa , FL , USA ;

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|February 26, 2016
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Summary
This summary is machine-generated.

Medical cannabis, including tetrahydrocannabinol (THC) and cannabidiol (CBD), shows efficacy for chronic pain and multiple sclerosis symptoms. While not FDA-approved in herbal form, specific cannabinoids offer therapeutic benefits, though potential adverse effects require careful patient consideration.

Keywords:
Cannabinoidscannabinoid treatmentmedical marijuana

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Area of Science:

  • Pharmacology and Therapeutics
  • Neuroscience
  • Pain Management

Background:

  • Herbal cannabis has a long history of medicinal use.
  • The discovery of tetrahydrocannabinol (THC), cannabidiol (CBD), and the endocannabinoid system has spurred research into cannabinoid medical applications.
  • Existing evidence supports cannabinoid efficacy for conditions like chronic cancer pain, neuropathic pain, and multiple sclerosis symptoms.

Purpose of the Study:

  • To explore the medical utility of cannabinoids.
  • To review the evidence supporting cannabinoid efficacy in various medical disorders.
  • To discuss patient selection criteria and potential adverse effects of medical cannabis.

Main Methods:

  • Review of existing scientific literature and clinical trial data on cannabinoid efficacy.
  • Analysis of regulatory standards (e.g., FDA approval) for medical cannabinoids.
  • Discussion of physician certification processes and patient counseling regarding medical cannabis use.

Main Results:

  • Substantial evidence supports the use of cannabinoids for chronic cancer pain, neuropathic pain, and multiple sclerosis symptoms.
  • While herbal cannabis lacks rigorous FDA approval, specific, well-characterized cannabinoids have met these standards.
  • Potential adverse effects include acute impairment, cannabis use disorder, cognitive impairment, and chronic bronchitis.

Conclusions:

  • Cannabinoids demonstrate therapeutic potential for specific debilitating medical disorders, particularly pain and MS symptoms.
  • Physician guidance is crucial for patient selection, informed consent regarding risks, and monitoring of adverse effects.
  • Ongoing research aims to optimize cannabinoid therapies by exploring novel ways to modulate the endocannabinoid system for enhanced benefits and reduced harm.